小儿喉炎患者T淋巴细胞亚群及痰液相关炎症细胞因子的变化

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目的研究喉炎患儿T淋巴细胞亚群及痰液相关炎症细胞因子的变化情况。方法选取50例喉炎患儿为观察组,50例健康同龄小儿为对照组,检测两组外周血T淋巴细胞亚群(CD3~+、CD4~+、CD8~+、CD4/CD8)、红细胞免疫(ATER、DTER、ETER、FEER、FEIR)及痰液炎症因子(IL-5、IL-8、IL-10、CRP、TNF-α)水平,并比较轻度、中度及重度喉炎患儿的上述指标检测水平。结果观察组的外周血CD3~+、CD4~+、CD4/CD8 T淋巴细胞亚群均明显低于对照组(P<0.05),CD8~+T细胞明显高于对照组(P<0.05);观察组ATER、DTER、ETER、FEER均低于对照组(P<0.05),FEIR则高于对照组(P<0.05);观察组的痰液相关炎症细胞因子水平均显著高于对照组(P<0.05)。重度喉炎患儿T淋巴细胞亚群、红细胞免疫水平均明显差于轻、中度患儿(P<0.05),中度患儿淋巴细胞亚群分布差于轻度患儿(P<0.05);重度患儿痰液相关炎症细胞因子水平高于轻中、度患儿(P<0.05),中度患儿痰液相关炎症细胞因子水平高于轻度患儿(P<0.05)。结论喉炎患儿综合免疫状态相对较差,痰液相关炎症细胞因子呈现较高的状态,其临床检测价值相对较高。 Objective To study the changes of T lymphocyte subsets and sputum related inflammatory cytokines in children with laryngitis. Methods Fifty children with laryngitis were selected as the observation group and 50 healthy children of the same age as the control group. T lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD4 / CD8) and erythrocytes (ATER, DTER, ETER, FEER, FEIR) and sputum inflammatory cytokines (IL-5, IL-8, IL-10, CRP and TNF-α) were measured and compared to mild, moderate and severe laryngitis Children above the level of detection indicators. Results The levels of CD3 +, CD4 +, CD4 / CD8 T lymphocytes in the peripheral blood of the observation group were significantly lower than those of the control group (P <0.05) and CD8 + T cells of the observation group were significantly higher than those of the control group (P <0.05). The levels of ATER, DTER, ETER and FEER in the observation group were significantly lower than those in the control group (P <0.05) and FEIR was higher in the observation group (P <0.05). The levels of sputum-related inflammatory cytokines in the observation group were significantly higher than those in the control group <0.05). The levels of T lymphocyte subsets and erythrocyte immunity in children with severe laryngitis were significantly lower than those in mild to moderate children (P <0.05). The distribution of lymphocyte subsets in children with moderate severe laryngeal inflammation was worse than that in mild children (P <0.05) (P <0.05). The sputum-related inflammatory cytokines in severe children were higher than those in mild to moderate children (P <0.05). The levels of sputum-related inflammatory cytokines in moderate children were higher than those in mild children (P <0.05). Conclusion The laryngitis children with relatively poor overall immune status, sputum-related inflammatory cytokines showed a higher status, the clinical test value is relatively high.
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