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目的观察药典法定剂量关木通水煎剂对大鼠肾功能及肾间质结构的影响。方法用药典规定剂量的关木通水煎剂给大鼠灌胃（1g／kg，约相当于人类剂量0．1g／kg），每日1次，共两个月。期间观察各项肾功能指标、肾脏组织形态学改变及细胞外基质（纤连蛋白）分布情况。结果关木通给药组的血肌酐水平、尿酶（NAG和γ－GT）活性、尿蛋白、尿糖与正常组大鼠相比无统计学差异。关木通给药组大鼠的肾组织形态结构在光镜下未见明显异常改变，其纤连蛋白的分布与正常组完全相同。结论药典法定剂量的关木通水煎剂对大鼠肾功能及肾间质结构无明显的不利影响。
Objective To observe the effect of Pharmacopoeia statutory dose Guan Mu Tong Shui Zhi on renal function and renal interstitial structure in rats. Methods The Pharmacopoeia prescribed dose of Guan Mu Tong decoction was given to rats (1 g/kg, equivalent to a human dose of 0.1 g/kg) once a day for two months. During the observation, various renal function indexes, renal morphological changes, and distribution of extracellular matrix (fibronectin) were observed. Results There was no significant difference in serum creatinine level, urinary enzyme (NAG and γ-GT) activity, urinary protein and urine glucose between normal and control groups. There was no obvious abnormality in the morphological structure of renal tissue in the Guanmutong-treated group under light microscope, and the distribution of fibronectin was exactly the same as that of the normal group. Conclusion The Pharmacopoeia statutory dose of Guanmutong decoction has no obvious adverse effect on renal function and renal interstitial structure in rats.