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目的探讨右旋糖酐40引起过敏性休克的临床特点及影响因素,为临床安全用药提供参考。方法收集1994年至2009年国内医学文献中右旋糖酐40致过敏性休克的病例报告进行统计分析。结果右旋糖酐40引起过敏性休克63例中,男性高于女性,高龄多于低龄,有基础疾病发生率较高,配伍复方丹参注射液发生率较高。结论右旋糖酐40可致严重过敏性休克,其发生主要与药物本身、患者的体质和原发疾病有关,临床应合理使用。
Objective To investigate the clinical characteristics and influential factors of dextran 40-induced anaphylactic shock and provide reference for clinical safety medication. Methods The cases of allergic shock induced by dextran 40 in domestic medical literature from 1994 to 2009 were collected for statistical analysis. Results dextran 40 caused by anaphylactic shock in 63 cases, men than women, older than younger, there is a higher incidence of underlying diseases, the compatibility of compound Salvia injection high incidence. Conclusion Dextran 40 can cause severe anaphylactic shock. The occurrence of dextran 40 is mainly related to the drug itself, the patient’s constitution and primary diseases, and should be used clinically.