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治疗痉挛的药物很多,替托尼定作为治疗痉挛的药物,最近在英国重新被确认,并可能替代氯苯氨了酸。该药是咪唑啉衍生物,为α_2肾上腺素能受体激动剂,对由脊髓和脊髓以上损伤所致肌强直及易感受伤害的活动有拮抗作用。它似乎对单突触活动没有影响。其作用机制包括:①减少在多突触途径中氨基酸类激动剂的释放;②减少后突触兴奋性递质的活动;③减少促去甲肾上腺素能蓝斑神经元的活动率;④减少感受伤害刺激在脊髓中的突触传递。
There are many drugs to treat spasticity, and tonitidine, a drug used to treat spasticity, has recently been re-confirmed in the UK and may replace chlorpheniramine. The drug is an imidazoline derivative that is an α 2 adrenergic receptor agonist that antagonizes myotonia and susceptibility to injury resulting from injury above the spinal cord and spinal cord. It seems to have no effect on monosynaptic activity. Its mechanism of action includes: (1) reducing the release of amino acid agonists in the synaptic pathway; (2) decreasing the activity of post-synaptic excitatory neurotransmitters; (3) decreasing the rate of activity of noradrenaline-stimulated locus coeruleus neurons Feeling hurt stimulates synaptic transmission in the spinal cord.