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本文旨在对原发性高血压恶性期存活患者的免疫学改变进行评价。本研究包括20例恶性原发性高血压患者和20例性别年龄相仿的血压正常的健康对照者。恶性高血压按WHO 的诊断标准,所有患者均经排除了继发性高血压。20例患者中13例(65%)已有4级视网膜改变,7例(35%)视网膜改变为3级(渗出和出血),15例病人(75%)有高血压家族史。以植物血凝素(PHA)、刀豆球蛋白(ConA)以及由冰冻干燥后从人主动脉组织中提取的动脉抗原作淋巴细胞转化试验;以 Jondal等法作 E-玫瑰花试验;以免疫荧光法测定免疫复合物;以放射免疫法测定血清中的免疫球蛋白(IgG、
This article aims to evaluate the immunological changes in patients with malignant stage of essential hypertension. This study included 20 patients with malignant essential hypertension and 20 healthy, normal-age, normotensive controls. Malignant Hypertension According to WHO diagnostic criteria, all patients were excluded from secondary hypertension. Retinal changes to grade 4 (exudation and hemorrhage) have occurred in 13 of 20 (65%), grade 4 (35%), and family history of hypertension in 15 patients (75%). Phytohemagglutinin (PHA), concanavalin (ConA) and lyophilized mouse arterial antigens from human aorta tissues were used for lymphocyte transformation test; the E-rose test was performed by Jondal et al. Immunofluorescence assay was used to measure the immunocomplex. Immunoglobulin (IgG,