1936年 DeQuarvain 和 Wegelin 二氏首先在缺碘病区发现了一批不是典型克汀病的亚临床病人,当时被称为“半克汀病(Se-micretin)”。从60年代后期起,随着研究的深入化,尤其在引入智力测验之后,许多学者都注意到这一事实:在缺碘地区的所谓正常人群中,有相当一部分人虽不能构成地方性克汀病的诊断,但实际上并不正常,他们既不是克汀病人也不能视为正常人。1979年 Connolly 氏注意到病区“正常”儿童存 In 1936, DeQuarvain and Wegelin II first identified a group of subclinical patients who were not typical cretinism in the iodine deficiency area, which was then called “Se-micretin.” Since the late 1960s, with the deepening of research, especially after the introduction of intelligence tests, many scholars have noticed the fact that quite a few of the so-called normal population in iodine deficient areas can not constitute endemic clintan The diagnosis of the disease, but in fact not normal, they are neither cretinid nor normal. In 1979 Connolly noticed that the ward was “normal” childish