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目的探讨血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(b FGF)在糖尿病视网膜病变中的表达及意义。方法 39例糖尿病视网膜病变白内障患者作为观察组(单纯型糖尿病视网膜病变21例,增殖型糖尿病视网膜病变18例),39例非糖尿病视网膜病变白内障患者作为对照组,分别对两组患者的血清进行取样,运用酶联免疫吸附试验(ELISA)方法测定两组血清中VEGF、b FGF的含量,观察两组患者血清VEGF、b FGF含量差异及观察组单纯型糖尿病视网膜病变与增殖型糖尿病视网膜病变患者之间VEGF、b FGF含量差异。结果观察组患者血清VEGF、b FGF含量(279.14±21.20)μg/L、(49.58±12.47)ng/L均明显高于对照组(163.12±20.13)μg/L、(29.09±11.43)ng/L,差异均具有统计学意义(P<0.05)。观察组增殖型糖尿病视网膜病变患者血清VEGF、b FGF含量(312.24±23.52)μg/L、(58.32±10.75)ng/L均高于单纯型糖尿病视网膜病变患者(256.12±26.45)μg/L、(49.76±8.49)ng/L,差异均具有统计学意义(P<0.05)。结论糖尿病视网膜病变的发生可能与VEGF、b FGF的高表达有关。
Objective To investigate the expression and significance of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b FGF) in diabetic retinopathy. Methods 39 cases of diabetic retinopathy cataract patients as observation group (21 cases of simple diabetic retinopathy, 18 cases of proliferative diabetic retinopathy) and 39 cases of non-diabetic retinopathy of cataract patients as a control group, respectively, the two groups of patients were sampled serum . The levels of VEGF and b FGF in the two groups were measured by enzyme-linked immunosorbent assay (ELISA). The difference of VEGF and b FGF in the two groups was observed, and the differences between the two groups were also observed. Between VEGF, b FGF content difference. Results The serum levels of VEGF and b FGF in the observation group (279.14 ± 21.20) μg / L and (49.58 ± 12.47) ng / L were significantly higher than those in the control group (163.12 ± 20.13 μg / L, 29.09 ± 11.43 ng / L , The differences were statistically significant (P <0.05). The levels of VEGF and b FGF in the patients with proliferative diabetic retinopathy (312.24 ± 23.52) μg / L and (58.32 ± 10.75) ng / L were significantly higher than those in simple diabetic retinopathy (256.12 ± 26.45) μg / L and 49.76 ± 8.49 ng / L, respectively, with statistical significance (P <0.05). Conclusion The occurrence of diabetic retinopathy may be related to the high expression of VEGF and b FGF.