Angew.Chem.Int.Ed.2013,52,10644~10647γ-氨基酸及其衍生物具有重要的生理功能和生物活性.与发展较为成熟的羰基化合物的α-氨化反应相比,对映选择性γ-氨化的方法非常缺少,是具有挑战性的研究课题.在发展系列卡宾催化烯酮及醛的对映选择性反应基础上,中国科学院化学研究所叶松等利用卡宾催化带离去基团的烯醛反应,生成手性双烯醇离子中间体,与偶氮化合物发 Angew.Chem.Int.Ed.2013,52,10644 ~ 10647γ-Amino acids and their derivatives have important physiological functions and biological activities.Compared with the α-amination reaction of more mature carbonyl compounds, the enantioselectivity Gamma-amination method is very lack of, is a challenging research topic.In the development of a series of carbene-catalyzed enone and aldehyde based on the enantioselective reaction based on the Chinese Academy of Sciences Institute of Chemistry Ye Song and other carbin catalytic band leaving group The enolic reaction of the enantiomers yields chiral dienoyl ion intermediates, with azo compounds