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目的研究哌拉西林钠对甲磺酸帕珠沙星在大鼠体内药代动力学的影响。方法 12只健康雄性SD大鼠随机分成2组(分别为单独和联合给药组),用HPLC法测定血浆中甲磺酸帕珠沙星的浓度。结果单独用药与联合用药组ρmax分别为(33.54±4.68)和(37.83±3.43)mg.L-1,AUC0-t分别为(43.32±15.91)和(41.98±9.19)mg.h.L-1,t1/2分别为(1.00±0.31)和(0.80±0.24)h,无显著性差异(P>0.05)。结论与哌拉西林钠联合用药后甲磺酸帕珠沙星在大鼠体内的药动学参数均不存在显著性差异。
Objective To study the effect of piperacillin sodium on the pharmacokinetics of pazufloxacin mesylate in rats. Methods Twelve healthy male Sprague-Dawley rats were randomly divided into 2 groups (separate and combined groups, respectively). The plasma concentrations of pazufloxacin mesylate were determined by HPLC. Results The ρmax were (33.54 ± 4.68) and (37.83 ± 3.43) mg.L-1, and the AUC0-t were (43.32 ± 15.91) and (41.98 ± 9.19) mg.hL-1, / 2 were (1.00 ± 0.31) and (0.80 ± 0.24) h, respectively, with no significant difference (P> 0.05). Conclusion Pazufloxacin mesylate combined with piperacillin sodium in rats pharmacokinetic parameters were not significantly different.