过去十多年来,已有越来越多的证据表明,氧化应激对心血管疾病,特别是高血压、动脉硬化、心肌肥厚及心功能衰竭的发生发展起着重要作用。尼克酰胺腺嘌呤二核苷酸磷酸氧化酶(nicotinamide-adenine dinucleotide phosphateoxidase,NADPH氧化酶)的激活是活性氧物质的主要来源,这些活性氧可以引起血管内皮功能障碍,细胞增殖, Over the past decade or so, there is more and more evidence that oxidative stress plays an important role in the occurrence and development of cardiovascular diseases, especially hypertension, arteriosclerosis, cardiac hypertrophy and heart failure. Activation of nicotinamide-adenine dinucleotide phosphate oxidase (NADPH oxidase) is a major source of reactive oxygen species that can cause vascular endothelial dysfunction, cell proliferation,