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目的探讨维吾尔族T2DM患者视网膜病变(DR)发病的相关因素。方法收集312例维吾尔族T2DM患者的临床资料,将所选病例按有无DR分为无DR组(NDR组)和有DR组(DR组)。其中,DR组又分为有糖尿病性肾脏疾病组(DKD组)和无DKD组(NDKD组)。结果维吾尔族T2DM患者DR发病率为25%(78/312)。DR组年龄、病程、体重、SBP、TC、FBG、HbA1c、LDL-C、血尿素氮(BUN)和肌酐(Cr)均显著高于NDR组(P<0.05);但WHR、DBP、TG、HDL-C、BMI两组之间无统计学差异(P>0.05)。Logistic回归分析结果显示,DM病程、患病年龄、SBP、FBG、TC、LDL-C、HbA1c、BUN、Cr和BMI是DR的危险因素(OR>1)。结论维吾尔族T2DM患者的DM病程、患病年龄、SBP、FBG、TC、LDL-C、HbA1c、BUN、Cr和BMI等参数与DR发病有相关性。
Objective To investigate the related factors of the pathogenesis of retinopathy (T2DM) in Uygur T2DM patients. Methods The clinical data of 312 Uighur T2DM patients were collected. The selected patients were divided into DR group (NDR group) and DR group (DR group) with or without DR. Among them, DR group was divided into diabetic nephropathy group (DKD group) and no DKD group (NDKD group). Results The incidence of DR in Uygur T2DM patients was 25% (78/312). DBP, TC, FBG, HbA1c, LDL-C, BUN and Cr in DR group were significantly higher than those in NDR group (P <0.05) There was no significant difference between HDL-C and BMI (P> 0.05). Logistic regression analysis showed that the duration of DM, SBP, FBG, TC, LDL-C, HbA1c, BUN, Cr and BMI were the risk factors for DR (OR> 1). Conclusion The DM duration, age at onset, SBP, FBG, TC, LDL-C, HbA1c, BUN, Cr and BMI in Uigur T2DM patients are correlated with the pathogenesis of DR.