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目的分析糖化血红蛋白、N末端脑钠肽原和急性冠脉综合征(ACS)心功能之间的相关性。方法选取ACS患者74例,以并发2型糖尿病的36例患者为Ⅰ组,以未并发2型糖尿病的38例患者为Ⅱ组,选取同期体检健康者36例为对照组,对比三组糖化血红蛋白和N末端脑钠肽原水平。结果Ⅰ组、Ⅱ组N末端脑钠肽原均显著高于对照组,且Ⅱ组显著高于Ⅰ组;Ⅱ组糖化血红蛋白水平显著高于Ⅰ组和对照组,且Ⅰ组和对照组无显著差异;随着患者心功能病情逐渐加重,患者糖化血红蛋白、N末端脑钠肽原水平逐渐升高。结论糖化血红蛋白、N末端脑钠肽原和ACS患者心功能有明显相关性,这两项指标可作为评估ACS患者心功能受损情况的主要指标。
Objective To analyze the correlation between glycosylated hemoglobin, N-terminal pro-brain natriuretic peptide and cardiac function in patients with acute coronary syndrome (ACS). Methods Thirty-four patients with ACS, 36 patients with type 2 diabetes mellitus (Group Ⅰ) and 38 patients without type 2 diabetes mellitus (Group Ⅱ) were enrolled. Thirty-six healthy subjects were enrolled in the study. The three groups of HbA1c And N-terminal pro-brain natriuretic peptide levels. Results The levels of N-terminal pro-brain natriuretic peptide in group Ⅰ and group Ⅱ were significantly higher than those in control group, and group Ⅱ was significantly higher than that in group Ⅰ. The level of glycated hemoglobin in group Ⅱ was significantly higher than that in group Ⅰ and control group, and there was no significant difference between group Ⅰ and control group Differences; With the patient’s cardiac function gradually aggravated, patients with glycosylated hemoglobin, N-terminal pro-brain natriuretic peptide levels gradually increased. Conclusions There is a significant correlation between HbA1c, N-terminal pro-brain natriuretic peptide and cardiac function in patients with ACS. These two indexes can be used as the main index to evaluate the cardiac function impairment in patients with ACS.