以环氧氯丙烷和脂肪醇为原料,通过相转移催化法合成了乙基、正丙基、正丁基和正戊基缩水甘油醚(1～4),并利用所合成的缩水甘油醚和β-环糊精为原料,分别在弱碱水溶液(1.5%)和强碱水溶液(30%)中制备并用硅胶柱分离出单2位取代的乙氧基、丙氧基、丁氧基和戊氧基-2-羟丙基-β-环糊精(1a～4a)和单6位取代的丙氧基、丁氧基和戊氧基-2-羟丙基-β-环糊精(2b～4b),利用薄层色谱、红外光谱、差热扫描量热分析、质谱和核磁共振等手段对所合成的产品进行了表征. Using epichlorohydrin and aliphatic alcohol as raw materials, ethyl, n-propyl, n-butyl and n-pentyl glycidyl ether (1-4) were synthesized by phase transfer catalysis. - cyclodextrin as starting material, respectively prepared in a weak base aqueous solution (1.5%) and a strong base aqueous solution (30%) and isolated by silica gel column single 2 substituted ethoxy, propoxy, butoxy and pentoxy 2-hydroxypropyl-β-cyclodextrin (1a-4a) and propoxy, butoxy and pentoxy- 4b). The synthesized products were characterized by TLC, FTIR, DSC, MS and NMR.