Mgers首先报道了高血糖可加剧实验鼠的缺血缺氧神经元损害,该作者又观察到禁食动物耐受心脏停搏14分钟而仅有轻微神经学方面改变,而停搏前输注葡萄糖则出现广泛灰质坏死.一些作者或持赞成意见,或持相反意见,因此探讨急性脑卒中与高血糖的关系,对促进神经功能恢复,防治脑水肿有重要意义.1糖尿病、高血糖与脑梗塞糖尿病能增加缺血性中风的发病,它是动脉粥样硬化性脑血管疾病的危险因素之一,糖尿病患者的脑梗塞预后不佳,且病死率也高于正常血糖者,这是因为糖尿病易引起颅内的血管粥样硬化及微动脉微血管瘤,毛细血管呈弥散和局灶性基膜增厚,另一方面,长期糖尿病发生脑血流自动调节受损,局部血流下降,同时有血动力学改变,加重微循环障碍,即糖尿病可致血小板粘附力增加,血管活性因子增多,从而导致脑梗塞发病率增加及其预后不良.Peress等发现供应基底节、丘脑、桥脑等矢状窦旁深穿动脉分布区,腔隙脑梗塞发病率较高,且随年龄变大而增加.说明在糖尿病导致脑梗塞中, Mgers first reported that hyperglycemia exacerbates hypoxic-ischemic neuronal damage in mice. The authors also observed that fasted animals tolerated cardiac arrest for 14 minutes with only minor neurological changes, while glucose was infused before arrest There is a wide range of gray matter necrosis.A few authors agree or agree, or take the opposite view, so to explore the relationship between acute stroke and hyperglycemia, for the promotion of neurological function, prevention and treatment of cerebral edema has important significance.1 diabetes, hyperglycemia and cerebral infarction Diabetes can increase the incidence of ischemic stroke, which is one of the risk factors of atherosclerotic cerebrovascular disease. The prognosis of cerebral infarction patients with diabetes is poor, and the mortality rate is also higher than those of normal blood sugar, which is due to diabetes Causing intracranial atherosclerosis and arteriolar microangioma, capillary diffusion and focal thickening of the basement membrane, on the other hand, long-term diabetes impaired cerebral blood flow auto-regulation, local blood flow decreased, while blood Kinetic changes, aggravating microcirculation, ie, diabetes can cause increased platelet adhesion, increased vasoactive factors, resulting in an increased incidence of cerebral infarction and poor prognosis. Supply of the basal ganglia, thalamus, pons and other parasagittal deep perforating artery distribution, lacunar infarction higher incidence increases with age becomes large. Explained cerebral infarction resulting from diabetes,