在免疫应答期间,可由相同克隆按不同比例合成具有不同中和活性的对称性和不对称性IgG分子,对称性IgG分子具有较高的中和活性,而不对称性IgG分子的中和活性则较低.人们曾以可溶性白蛋白免疫家兔,结果证实当抗原与细菌一起接种时,所产生的不对称性抗体分子的比率较同一抗原单独接种时高.鉴于这一发现,作者对百日咳无细胞或全细胞菌苗DTP免疫家兔后所产生的抗破伤风类毒素抗体的中和活性进行了研究.作者用百日咳无细胞菌苗DTP(DTaP) Symmetrical and asymmetric IgG molecules with different neutralizing activities can be synthesized from the same clones at different rates during the immune response. Symmetric IgG molecules have a higher neutralizing activity whereas asymmetric IgG molecules neutralize Lower.A human has been immunized with soluble albumin, the results confirmed that when the antigen is inoculated with bacteria, the resulting asymmetric antibody molecules than the same antigen alone when vaccinated high in view of this finding, the author of pertussis Neutralizing activity of anti-tetanus toxoid antibodies produced by immunization of rabbits with cells or whole-cell vaccine DTP was studied.With the use of acellular pertussis vaccine DTP (DTaP)