乙型肝炎病毒反复感染导致的肝纤维化、肝硬化目前尚未有有效的治疗措施,尽管肝移植为终末肝患者提供了有效的治疗方法,得以延长生命,但由于供肝来源有限,费用昂贵,限制了其临床应用,近几年国外动物实验[1,2]和临床研究表明[3-6],骨髓干细胞能分化为肝细胞,并参与肝细胞的再生, Hepatic fibrosis and cirrhosis caused by recurrent hepatitis B virus have not yet been effectively treated. Although liver transplantation provides an effective treatment for end-stage liver disease and prolongs life, it is expensive due to limited sources of liver supply , Limiting its clinical application, in recent years, foreign animal experiments [1,2] and clinical studies have shown that [3-6], bone marrow stem cells can differentiate into hepatocytes, and participate in the regeneration of liver cells,