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骨肉瘤是实体性的肿瘤且血运丰富,其生长和转移都有依赖于肿瘤中血管的生成。已发现多种骨肉瘤血管生成相关的因子,其中一些血管生成因子和患者的预后及病程转归密切相关。文中就近年发现和骨肉瘤预后相关的血管生成因子:血管内皮生长因子(vascular endothelial growth factor,VEGF)、基质金属蛋白酶(matrix metalloproteinase,MMP)、血小板衍生生长因子(platelet-derived growth factor,PDGF)、表皮生长因子受体(epidermal growth factor receptor,EGFR)、色素上皮衍生因子(pigment epithelium-derived factor,PEDF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)做一综述。
Osteosarcoma is a solid tumor and rich in blood supply, its growth and metastasis are dependent on the formation of blood vessels in the tumor. A variety of osteosarcoma angiogenesis related factors have been found, some of which are closely related to the prognosis and course of disease. In the recent years, we found that angiogenic factors related to prognosis of osteosarcoma: vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP), platelet-derived growth factor (PDGF) , Epidermal growth factor receptor (EGFR), pigment epithelium-derived factor (PEDF) and basic fibroblast growth factor (bFGF).