MicroRNAs (miRNAs) have been demonstrated to involve in multiple biological processes,including apoptosis,proliferation,differentiation,and metastasis [1-3].In addition,several groups have reported that abnormalities of specific miRNAs are implicated in cancer pathogenesis [4,5].The roles of miR-224 and miR-145 in tumorigenesis have attracted the attention of many researchers.The protein A disintegrin and metalloproteinase 17 (ADAM17) is overexpressed in many types of cancers,including hepatocellular carcinoma (HCC).ADAM17 expression is regulated by multiple miRNAs,which have been identified in several types of cancers [6,7].In silico analysis suggested that ADAM17 is a common target of both miR-224 and miR-145.In the present study,we investigated the expression and distribution of miR-224,miR-145,and ADAM17 in HCC samples and analyzed the relationship between both miRNAs and ADAM17.