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目的:观察重型肝炎患者胆固醇水平与空腹血糖水平的变化,分别探讨二者对重型肝炎患者病情及预后的影响。方法:收集2008年6月至2013年10月我院289例重型肝炎患者,根据其胆固醇水平与空腹血糖水平进行分组,对各组之间的病死率进行比较分析。结果:重型肝炎患者的血胆固醇均低于正常范围;重度低胆固醇组病死率明显高于轻度低胆固醇组(χ2=45.80,P<0.05)。血糖异常组病死率明显高于血糖正常组(χ2=10.72,P<0.05);轻、中和重度低血糖组之间的病死率具有统计学差异(χ2=45.31,P<0.05)。结论:重型肝炎患者胆固醇水平越低,空腹血糖水平越低,其病死率越高,预后越差。
Objective: To observe the changes of serum cholesterol and fasting blood glucose in patients with severe hepatitis, and to investigate their effects on the severity and prognosis of patients with severe hepatitis. Methods: From June 2008 to October 2013, 289 patients with severe hepatitis in our hospital were collected and divided into groups according to the level of cholesterol and fasting blood glucose. The mortality of each group was compared and analyzed. Results: Serum cholesterol in patients with severe hepatitis was lower than normal range. The mortality rate in severe low cholesterol group was significantly higher than that in mild hypocholesterolemia group (χ2 = 45.80, P <0.05). The mortality of patients with abnormal glucose was significantly higher than that of patients with normal glucose (χ2 = 10.72, P <0.05). There was a significant difference in mortality between mild and moderate hypoglycemia groups (χ2 = 45.31, P <0.05). Conclusion: The lower the level of cholesterol in patients with severe hepatitis, the lower the fasting blood glucose level, the higher the mortality rate, the poorer the prognosis.