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目的探讨肾移植患者口服吗替麦考酚酯和麦考酚钠肠溶片的药代动力学及有效性。方法选取2013年4月至2014年4月门诊收治住院的38例肾移植患者,将其依照住院号尾号的奇偶数分为两组,各19例。试验组患者采用口服吗替麦考酚酯治疗,对照组患者采用口服麦考酚钠肠溶片治疗,比较分析两组患者的治疗效果及其药代动力学情况。结果试验组患者治疗总有效率为94.7%,对照组患者总有效率为84.2%,差异有统计学意义(P<0.05);试验组患者在吸收、分布、代谢、排泄各方面均优于对照组,差异均有统计学意义(均P<0.05)。两组患者不良反应比较,差异有统计学意义(P<0.05)。结论口服吗替麦考酚酯免疫抑制剂治疗的肾移植受者,临床治疗效果好,反复给药可起到药物的蓄积作用达到治疗目的。
Objective To investigate the pharmacokinetics and efficacy of oral mycophenolate mofetil and mycophenolate sodium enteric-coated tablets in renal transplant recipients. Methods Thirty-eight patients admitted to our hospital from April 2013 to April 2014 were selected and divided into two groups according to the odd and even numbers of the tail number. Patients in the test group were treated with oral mycophenolate mofetil. Patients in the control group were treated with oral mycophenolate mofetil. The therapeutic effects and pharmacokinetics of the two groups were compared. Results The total effective rate was 94.7% in the experimental group and 84.2% in the control group, with significant difference (P <0.05). The experimental group was superior to the control in absorption, distribution, metabolism and excretion Group, the differences were statistically significant (all P <0.05). Adverse reactions between the two groups, the difference was statistically significant (P <0.05). Conclusion Oral injection of mycophenolate mofetil for immunosuppressant treatment of renal transplant recipients, clinical treatment effect is good, repeated administration can play a role in the accumulation of drugs to achieve therapeutic purposes.