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应用饱和硫酸铵制备纯化纤维蛋白原 ,硫代巴妥酸法测定了肝硬化患者纤维蛋白原结合唾液酸(FSA)的水平 ,结果显示病人的纤维蛋白原结合唾液酸水平 2 3.6± 2 .6nmul/mg ,显著高于正常对照组 18.4± 3.7mol/mg(P <0 .0 1) ,并且凝血酶时间的延长与FSA的升高呈高度正相关 (P <0 .0 1) ;纤维蛋白单体聚合的速度与纤维蛋白原结合唾液酸成反比。表明纤维蛋白原结合唾液酸的水平可作为诊断肝硬化获得性异常纤维蛋白血症的理想指标。
Purified fibrinogen was prepared using saturated ammonium sulfate, and the level of fibrinogen-bound sialic acid (FSA) in patients with cirrhosis was measured by thiobarbituric acid. The results showed that the fibrinogen-binding sialic acid level of patients was 3.6 ± 2.6 nmul / mg, which was significantly higher than that of the normal control group (18.4 ± 3.7mol / mg, P <0.01). The prolongation of thrombin time was positively correlated with the increase of FSA (P <0.01) The rate of monomer polymerization is inversely proportional to the binding of fibrinogen to sialic acid. This indicates that the level of fibrinogen-binding sialic acid may be an ideal indicator for diagnosis of acquired cirrhosis-acquired dysfunctional fibrinogen.