论文部分内容阅读
目的研究阿卡波糖治疗老年人餐后低血压的有效性和安全性。方法 43例病情平稳的老年餐后低血压患者,予阿卡波糖(每次50mg,每日3次)治疗1d,筛选日和干预日3餐均进标准餐,监测进餐前后、治疗前后的血压、心率、血糖,同时测定治疗前左室射血分数、左室短轴缩短率。结果与治疗前相比,治疗后早餐收缩压、舒张压、平均动脉压(P<0.05)下降幅度明显减小,中餐仅平均动脉压(P<0.05),晚餐舒张压、平均动脉压(P<0.05)下降幅度明显减小,心率变化(P>0.05)在3餐均差异无统计学意义。左室射血分数、左室短轴缩短率与缓解比值呈正相关(r=0.35,P<0.05;r=0.42,P<0.05);阿卡波糖治疗餐后低血压有效率达62.79%,药物不良反应发生率为9.30%。结论阿卡波糖治疗老年人餐后低血压安全有效。
Objective To study the efficacy and safety of acarbose in the treatment of postprandial hypotension in the elderly. Methods Forty-three patients with stable postprandial hypotension were treated with acarbose (50mg daily for 3 days) for 1 day. The screening meals and interventional day 3 meals were given standard meal before and after meals, before and after treatment Blood pressure, heart rate, blood glucose, left ventricular ejection fraction before treatment, shortening of left ventricular shortening. Results Compared with that before treatment, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure (P <0.05) decreased significantly after treatment. Mean arterial pressure (P <0.05), diastolic blood pressure, mean arterial pressure <0.05) decreased significantly, heart rate changes (P> 0.05) in 3 meals were no significant difference. Left ventricular ejection fraction, shortening of left ventricular short axis and mitigation rate was positively correlated (r = 0.35, P <0.05; r = 0.42, P <0.05); acarbose treatment of postprandial hypotension was 62.79% The incidence of adverse drug reactions was 9.30%. Conclusions Acarbose is safe and effective in treating postprandial hypotension in the elderly.