肿瘤的浸润与转移是一个复杂的多阶段过程，金属蛋白酶通过对细胞外基质的降解促进肿瘤细胞浸润与转移，而金属蛋白酶组织抑制因子则可下调金属蛋白酶的活性而抑制肿瘤的浸润与转移，金属蛋白酶在各个水平上的调控，为抗肿瘤治疗，特别是抑制肿瘤的浸润与转移提供了有效的途径。 Tumor invasion and metastasis is a complex multi-stage process. Metalloproteinases promote the infiltration and metastasis of tumor cells through the degradation of extracellular matrix. Tissue inhibitors of metalloproteinases can down-regulate the activity of metalloproteinase and inhibit the invasion and metastasis of tumor. The regulation of metalloproteinases at various levels provides an effective way for anti-tumor therapy, especially for inhibiting tumor invasion and metastasis.