论文部分内容阅读
Poly(ADP-ribose)polymerase 1(PARP-1)是Poly(ADP-ribose)聚合物(PAR)合成的催化酶,在脑缺血损伤早期即出现过表达,通过加剧细胞内能量消耗及诱导AIF核转位等机制导致脑细胞发生“Parthanatos”样死亡。同时,PARP-1作为(NF)-κB辅助因子,参与脑缺血后炎症调控。此外PARP-1过表达通过破坏缺血区血管内皮细胞、诱导MMPs表达等途径加重脑梗后出血转化。以上机制均加重脑缺血损伤,因此开发有效PARP-1抑制剂将可望为脑缺血卒中后脑保护治疗带来全新前景,但应注意到PARP-1在脑缺血损伤作用存在性别差异问题。
Poly (ADP-ribose) polymerase 1 (PARP-1), a catalytic enzyme catalyzed by Poly (ADP-ribose) polymer (PAR), appears to be overexpressed in the early stage of cerebral ischemic injury by increasing intracellular energy expenditure and inducing AIF Mechanisms such as nuclear translocation lead to “Parthanatos” death of brain cells. Meanwhile, PARP-1 is involved in the regulation of inflammation after cerebral ischemia as a cofactor of (NF) -κB. In addition, PARP-1 overexpression aggravates hemorrhage and conversion after cerebral infarction by destroying vascular endothelial cells in ischemic area and inducing MMPs expression. These mechanisms are aggravating cerebral ischemic injury, therefore, the development of effective inhibitors of PARP-1 will be expected to provide a new prospect for cerebral protection after cerebral ischemic stroke, but it should be noted PARP-1 in the role of gender differences in cerebral ischemia injury problems .