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目的观察冠心病不同类型患者氧化低密度脂蛋白(oxLDL)水平的变化及其与细胞因子之间的关系,探讨二者在急性冠状动脉综合征(ACS)发病中的作用和临床意义。方法采用酶联免疫吸附法测定ACS组(50例)、稳定型心绞痛组(46例)和正常对照组(45例)血浆oxLDL、肿瘤坏死因子α(TNFα)和白细胞介素6(IL6)的水平。结果ACS组oxLDL、TNFα和IL6水平均显著高于稳定型心绞痛组和正常对照组(P<0.01);稳定型心绞痛组oxLDL和IL6水平均显著高于正常对照组(P<0.01),但TNFα水平在两组间比较差异无统计学意义(P>0.05)。ACS患者血浆oxLDL水平与TNFα呈显著正相关(r=0.485,P<0.01),与IL6呈显著正相关(r=0.574,P<0.01)。结论ACS患者血浆oxLDL和细胞因子TNFα、IL6水平均明显升高,且呈显著正相关,升高的程度可以作为炎症反应增强和病情严重程度判断的指标之一。
Objective To investigate the changes of oxidized low density lipoprotein (oxLDL) and its relationship with cytokines in different types of patients with coronary heart disease (CHD) and to explore their roles in the pathogenesis of acute coronary syndrome (ACS) and their clinical significance. Methods The levels of plasma oxLDL, TNFα and IL6 in ACS group (50 cases), stable angina group (46 cases) and normal control group (45 cases) were determined by enzyme linked immunosorbent assay Level. Results The levels of oxLDL, TNFα and IL6 in ACS group were significantly higher than those in stable angina group and normal control group (P <0.01). The levels of oxLDL and IL6 in stable angina group were significantly higher than those in normal control group (P <0.01) There was no significant difference in the level between the two groups (P> 0.05). The level of plasma oxLDL in ACS patients was positively correlated with TNFα (r = 0.485, P <0.01), and positively correlated with IL6 (r = 0.574, P <0.01). Conclusions The levels of plasma oxLDL, TNFα and IL-6 in ACS patients were significantly increased and positively correlated with each other. The extent of the increase can be regarded as one of the indicators of enhanced inflammatory response and severity of illness.