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目的 研究不同病程尖锐湿疣(CA)患者血清γ干扰素(IFN-γ)、白细胞介素-2 (IL-2)及白细胞介素-4(IL-4)水平的变化在CA免疫发病机制中的作用。方法 采用双抗体夹心ELISA法,检测了60例不同病程CA患者血清IFN-γ、IL-2及IL-4水平。结果 CA患者组血清IFN-γ、IL-2水平明显低于健康对照组(P<0.01),而CA长病程组血清IFN-γ、IL-2水平明显低于CA短病程组(P<0.01);CA患者组血清IL-4水平明显高于健康对照组(P<0.01),而CA长病程组血清IL-4水平明显高于CA短病程组(P<0.01)。结论 CA患者有Th1型细胞因子表达低下和Th2型细胞因子表达亢进,长病程患者更明显,患者Th1型细胞因子表达低下和Th2型细胞因子表达亢进在CA的免疫发病机制中可能起重要作用。
Objective To investigate the changes of serum levels of interferon-γ (IFN-γ), interleukin-2 (IL-2) and interleukin-4 (IL-4) in patients with condyloma acuminatum (CA) Role. Methods Serum levels of IFN-γ, IL-2 and IL-4 in 60 CA patients with different course of disease were detected by double antibody sandwich ELISA. Results The levels of serum IFN-γ and IL-2 in patients with CA were significantly lower than those in healthy controls (P <0.01), while the levels of serum IFN-γ and IL-2 in CA with long courses were significantly lower than those in patients with CA ). The level of serum IL-4 in patients with CA was significantly higher than that in healthy controls (P <0.01). The level of serum IL-4 in patients with long-term CA was significantly higher than that in patients with short courses of CA (P <0.01). CONCLUSIONS: Patients with CA have low expression of Th1 cytokines and elevated Th2 cytokines, and patients with long course of disease are more obvious. The low expression of Th1 cytokines and the increase of Th2 cytokines may play an important role in the pathogenesis of CA.