肝衰竭是多种因素导致肝脏严重损害的一组临床症候群,其中慢加急性肝衰竭(acute on chronic liv-er failure,ACLF)最为常见,病死率高,预后极差,因而受到广泛关注。近年来在ACLF的定义、发病机制、治疗、预后判断方面取得一些进展,现简述如下。一、ACLF的定义和诊断进展 Liver failure is a group of clinical syndromes caused by many factors leading to serious liver damage. Among them, ACLF is the most common, with high mortality and poor prognosis. In recent years, some progresses have been made in the definition, pathogenesis, treatment and prognosis of ACLF, which are summarized as follows. First, the definition and diagnosis of ACLF progress