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目的:探讨高海拔地区与低海拔地区非霍奇金淋巴瘤（NHL）化疗过程中凝血酶原时间（PT）的变化及其临床意义，了解NHL与PT的关系。方法:收集2018年8月至2019年9月高海拔地区青海省第五人民医院（平均海拔2 261 m）及低海拔地区天津市第四中心医院（平均海拔1.3 m）各68例NHL患者，分别与20例高海拔地区和20例低海拔地区健康体检者比较PT；根据患者分型、分期及分级[国际预后指数（IPI评分）]分组对比高低海拔地区NHL患者初诊PT；比较高低海拔地区患者化疗6个周期后的PT变化。结果:低海拔地区健康体检者及NHL患者初诊PT均低于高海拔地区[（12.3 ± 1.3） s比（13.4 ± 1.9） s、（12.2 ± 0.8） s比（13.7 ± 1.1） s]，差异均有统计学意义（n P0.05）；高海拔与低海拔地区NHL患者不同分型、分期及分级PT比较差异均有统计学意义（n t =4.611、8.202、6.893、5.345、3.121、5.397、2.838、3.720，n P0.05）；高海拔与低海拔地区NHL患者化疗前后PT比较[（13.7 ± 1.1） s比（12.2 ± 0.8） s、（13.4 ± 1.4） s比（12.0 ± 1.3） s]，差异均有统计学意义（n P0.05）。n 结论:低海拔地区NHL患者PT低于高海拔地区，与NHL患者分型、分期、分级及化疗无明显关系。“,”Objective:To investigate the changes and clinical significance of prothrombin time (PT) during chemotherapy for non-Hodgkin lymphoma (NHL) in high-altitude area and low-altitude area, and understand the relationship between NHL and PT.Methods:From August 2018 to September 2019, data of 68 cases of NHL patients in the Fifth People′s Hospital of Qinghai Province in the high-altitude area (average altitude: 2 261 m) and the Tianjin Fourth Central Hospital in the low-altitude area (average altitude: 1.3 m) were collected and compared with those of 20 subjects from health examination. The patients were divided into groups according to the NHL classification, stage and grade (international prognostic index, IPI score), the PT at initial diagnosis was compared. The PT changes before and after chemotherapy (6 cycles) were compared between high-altitude area and low-altitude area.Results:The PT in healthy subjects and PT at initial diagnosis in NHL patients in low-altitude area were lower than those in high-altitude area: (12.3 ± 1.3) s vs. (13.4 ± 1.9) s, (12.2 ± 0.8) s vs. (13.7 ± 1.1) s, and there was statistical difference (n P0.05). In NHL patients in high-altitude area and low-altitude area, PT of different NHL classification, stage and grade were statistically significant (n t = 4.611, 8.202, 6.893, 5.345, 3.121, 5.397, 2.838 and 3.720, n P 0.05); in NHL patients, there were statistically significant differences in PT before and after chemotherapy between high-altitude area and low-altitude area: (13.7 ± 1.1) s vs. (12.2 ± 0.8) s, (13.4 ± 1.4) s vs. (12.0 ± 1.3) s, and there were statistical differences (n P0.05).n Conclusions:PT of NHL patients in low-altitude area is lower than that in high-altitude area, and there is no significant correlation with NHL classification, stage, grade and chemotherapy in NHL patients.