本实验采用雄性Wistar大鼠39只,体重180～220 g,分成溃疡组、盐水组和空白组。溃疡组在无菌条件下打开腹腔,将少量冰醋酸注射入胃粘膜下层,造成胃溃疡;盐水组模拟手术,用等量生理盐水代替冰醋酸;空白组为正常大鼠。于手术后4～28天分批取材,进行超微结构的观察。盐水组:手术后4～6天,甲状腺滤泡细胞变得扁平,顶部质膜光滑,微绒毛减少。胶体小滴、溶酶体和分泌颗粒的数目减少,粗面内质网和高尔 In this study, 39 male Wistar rats weighing 180-220 g were divided into ulcer group, saline group and blank group. In the ulcer group, the abdominal cavity was opened under aseptic conditions, and a small amount of glacial acetic acid was injected into the gastric submucosa to cause gastric ulcer. The saline group was operated under simulated operation, with the same amount of normal saline instead of glacial acetic acid. The blank group was normal rats. 4 to 28 days after surgery taken in batches, the ultrastructure of the observation. Saline group: 4 to 6 days after surgery, the thyroid follicular cells became flattened, the top of the plasma membrane was smooth and the number of microvilli was reduced. Colloid droplets, reduced numbers of lysosomes and secretory granules, rough endoplasmic reticulum and Gall