论文部分内容阅读
目的探讨高尿酸血症(hyperurcemia,HUA)与急性脑梗死(acute cerebral infarction,ACI)的关系。方法89例ACI患者为脑梗死组,空腹12h后测定血尿酸(UA),总胆固醇(TC),高密度脂蛋白(HDL),低密度脂蛋白(LDL)和甘油三酯(TG);设87例同期住院年龄、性别相匹配的无脑梗死老人为对照组。结果ACI组高尿酸者62例(≥420mmol/L),占69.66%。与对照组血尿酸值存在差异显著性(P<0.01)。同时在脑梗死组中,对血尿酸与HDL、TC、TG进行的相关分析结果显示UA与其他三项差异无显著性(P>0.05)。结论HUA与ACI间存在着密切关系,是独立于血脂之外的ACI危险因素,血尿酸值增高可能是ACI的危险因素之一。结果脑梗死组和对照组空腹血尿酸升高分别为62例和11例,占69.66%和12.64%,血浆尿酸浓度分别为482.5umol/L±90.12umol/L及315.13umol/L±89.12umol/L,差异有统计学意义。脑梗死组尿酸结果明显高于对照组,两组比较有显著性差异(P<0.01)。
Objective To investigate the relationship between hyperuricemia (HUA) and acute cerebral infarction (ACI). Methods Eighty-nine ACI patients were divided into three groups: cerebral infarction group, fasting blood urea nitrogen (UA), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) Eighty-seven elderly patients without cerebral infarction matched for hospitalization age and gender at the same period were taken as control group. Results In the ACI group, 62 cases of hyperuricemia (≥420mmol / L) accounted for 69.66%. The level of serum uric acid in the control group was significantly different (P <0.01). At the same time in the cerebral infarction group, the correlation analysis of serum uric acid with HDL, TC, TG showed no significant difference between UA and the other three (P> 0.05). Conclusion There is a close relationship between HUA and ACI, which is an independent risk factor of ACI independent of blood lipid. One of the risk factors of ACI is the increase of serum uric acid. Results The levels of fasting serum uric acid in cerebral infarction group and control group were 62 and 11 cases, accounting for 69.66% and 12.64% respectively. The plasma uric acid concentrations were 482.5umol / L ± 90.12umol / L and 315.13umol / L ± 89.12umol / L, the difference was statistically significant. Uric acid in cerebral infarction group was significantly higher than that in control group, there was significant difference between the two groups (P <0.01).