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目的:观察伴院内感染早产儿血清C反应蛋白(CRP)水平的动态变化。方法:根据是否伴有院内感染将130例早产儿分为无院内感染的对照组105例和伴院内感染组25例,分别于出生后第1、3、5、7、9天采集早产儿足跟血,采用双抗体夹心法检测两组早产儿不同时间点的血清CRP水平动态变化。结果:伴院内感染组早产儿不同感染原因其血清CRP水平峰值相异,以皮肤感染最低,败血症最高,表现为皮肤感染<尿路感染<呼吸道感染<败血症。对照组早产儿血清CRP水平在监测期间未发生显著变化(P>0.05)。伴院内感染组早产儿出生后第1天血清CRP水平明显高于对照组(P<0.05),第3天升高达峰值,治疗后从出生后第5天逐渐下降,第7天仍高于对照组(P<0.05),至第9天接近对照组(P>0.05)。结论:动态监测血清CRP水平的变化对伴院内感染早产儿的临床防治具有较好的价值。
Objective: To observe the dynamic changes of serum C-reactive protein (CRP) in premature infants with nosocomial infection. Methods: 130 preterm infants were divided into nosocomial infection control group (n = 105) and nosocomial infection group (n = 25) according to whether they had nosocomial infection. Preterm infants were collected on the 1st, 3rd, 5th, 7th and 9th day Followed by blood, using double antibody sandwich method to detect serum CRP levels in two groups of premature children at different time points dynamic changes. Results: The highest CRP levels were found in different prenatal neonates with nosocomial infection, the lowest in skin infection and the highest in sepsis. Skin infections (urinary tract infections 0.05). Serum CRP levels in preterm infants with nosocomial infection group were significantly higher than those in control group on the first day after birth (P <0.05), peaked on the third day, gradually decreased from the fifth day after birth to the seventh day after birth Group (P <0.05), and close to the control group on the 9th day (P> 0.05). Conclusion: The dynamic monitoring of serum CRP level changes with the prevention and treatment of nosocomial infection in premature children with good value.