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目的探讨CD71、CD80在紫癜性肾炎(HSPN)患者肾脏损害中的作用以及CD71与IgA的关系。方法采用SP法检测免疫标记IgA、CD71、CD80在肾组织的表达情况。结果与正常对照组相比,CD71表达与BUN和ALB组间的差异有统计学意义。CD80表达与24 h尿蛋白定量、尿蛋白定性、BUN、ALB组间的差异有统计学意义。病理分型与CD71的表达呈负相关。结论 HSPN患者CD71均仅在远曲小管表达,CD80表达于近曲小管、远曲小管及肾间质,IgA均表达于肾小球系膜和/或毛细血管袢。IgA的表达与CD71的表达无相关性。
Objective To investigate the role of CD71 and CD80 in kidney damage in patients with purpura nephritis (HSPN) and the relationship between CD71 and IgA. Methods SP immunohistochemical method was used to detect the expression of IgA, CD71 and CD80 in renal tissue. Results Compared with normal control group, there was significant difference between CD71 expression and BUN and ALB groups. CD80 expression and 24 h urinary protein, urine protein qualitative, BUN, ALB group differences were statistically significant. Pathological classification and expression of CD71 was negatively correlated. Conclusions CD71 in HSPN is only expressed in distal convoluted tubules. CD80 is expressed in proximal convoluted tubule, distal convoluted tubule and renal interstitium. IgA is expressed in mesangial and / or capillaries. No correlation was found between IgA expression and CD71 expression.