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目的采用Meta分析法探讨幽门螺杆菌(Hp)与胃食管反流病(GERD)的关系。方法以GERD组与对照组的HP阳性数的OR值为效应指标,根据一致性检验的结果,选择随机效应模型对OR值进行合并,同时进行偏倚评估。结果纳入总样本量为4 888例,其中GERD组为2 160例,对照组为2 728例;Meta分析合并OR=0.55,95%CI:0.43～0.72。漏斗图形虽不对称,但经敏感性分析结果显示,发表偏倚对研究结果影响较小。结论 HP感染与GERD的发生有关。
Objective To investigate the relationship between Helicobacter pylori (Hp) and gastroesophageal reflux disease (GERD) by Meta-analysis. Methods The odds ratio (OR) of HP-positive numbers in GERD group and control group was taken as the effect index. According to the result of the consistency test, the random effect model was selected to combine the OR values and evaluate the bias. Results The total sample size was 4888, of which 2 160 in the GERD group and 2 728 in the control group, and OR = 0.55 and 95% CI 0.43 to 0.72 in the meta-analysis. Although the funnel pattern is not symmetrical, the results of sensitivity analysis show that publication bias has little effect on the research results. Conclusion HP infection is related to the occurrence of GERD.