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[目的]探讨C反应蛋白(CRP)、白细胞介素(IL)-8及细胞间黏附分子-1(ICAM-1)与支气管哮喘急性发作的关系.[方法]采集哮喘急性发作组及缓解组患者静脉血,离心后取血清,利用免疫透射比浊法检测CRP水平,采用酶联免疫吸附法测定IL-8及ICAM-1水平,以28例健康体格检查者作为对照组.[结果]哮喘急性发作组血清CRP,IL-8及ICAM-1水平较缓解组及对照组均明显升高(P<0.01),缓解组血清IL-8和ICAM-1水平与对照组比较均显著增高(P<0.01).[结论]血清CRP,IL-8及ICAM-1水平检测可作为支气管哮喘急性发作期病情分期评估指标.
[Objective] To investigate the relationship between C-reactive protein (CRP), interleukin (IL) -8 and intercellular adhesion molecule-1 (ICAM-1) and acute exacerbation of bronchial asthma. [Methods] The venous blood of patients was taken out, the serum was taken after centrifugation, the level of CRP was measured by immunoturbidimetry, the levels of IL-8 and ICAM-1 were measured by enzyme-linked immunosorbent assay (ELISA), and 28 healthy people were used as control group. [Results] The levels of serum CRP, IL-8 and ICAM-1 in acute exacerbation group were significantly higher than those in remission group and control group (P <0.01), and the levels of IL-8 and ICAM-1 in remission group were significantly higher than those in control group <0.01). [Conclusions] Serum levels of CRP, IL-8 and ICAM-1 can be used as the evaluation index of stage of asthma exacerbation.