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目的探讨甲状腺功能亢进症(甲亢)对部分骨代谢生化指标的影响。方法 105例甲亢患者,按骨密度(BMD)测定结果分为骨量正常组(58例)、骨量减低组(34例)和骨质疏松组(13例)。所有患者均测定血清钙、镁、磷、碱性磷酸酶(ALP)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺素(T_SH)水平,并比较三组的差异。结果骨量正常组血清钙、磷、ALP、FT_3、FT_4显著低于骨量减低组及骨质疏松组,而血清镁显著高于骨量减低组及骨质疏松组(P<0.05)。相关性分析显示,血清钙、磷、ALP、FT_4与腰椎(L_(2~4))、股骨颈BMD呈负相关(P<0.01),血清镁与腰椎、股骨颈BMD呈正相关(P<0.01)。结论甲亢患者可出现不同程度的骨代谢紊乱,在治疗甲亢同时应常规行BMD检查,积极防治甲亢性骨病的发生。
Objective To investigate the effect of hyperthyroidism (hyperthyroidism) on the biochemical markers of partial bone metabolism. Methods 105 patients with hyperthyroidism were divided into normal group (58 cases), osteopenia group (34 cases) and osteoporosis group (13 cases) according to the BMD results. All patients were measured serum levels of calcium, magnesium, phosphorus, alkaline phosphatase (ALP), free triiodothyronine (FT_3), free thyroxine (FT_4), thyrotropin (T_SH) difference. Results The levels of serum calcium, phosphorus, ALP, FT_3 and FT_4 in normal bone mass group were significantly lower than those in osteopenia group and osteoporosis group, while serum magnesium was significantly higher than those in osteopenia group and osteoporosis group (P <0.05). Correlation analysis showed that serum calcium, phosphorus, ALP and FT_4 were negatively correlated with lumbar spine (L_ (2-4)) and femoral neck BMD (P <0.01), serum magnesium was positively correlated with lumbar spine and femoral neck BMD ). Conclusion Hyperthyroidism patients may present with varying degrees of bone metabolism disorders. In the treatment of hyperthyroidism, BMD should be routinely performed to prevent and treat hyperthyroidism.