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目的探讨药物联合治疗糖尿病肾病的临床研究。方法将120例糖尿病肾病(DN)患者随机分为观察组、对照组A、对照组B三组,各40例,观察三组治疗前后血压、24h尿蛋白变化。结果三组治疗后血压和尿蛋白均显著下降(P<0.05),观察组下降程度大于A、B组(P<0.05)。结论贝那普利联合缬沙坦治疗DN较单独用药疗效确切,安全性高。
Objective To investigate the clinical study of drug combination therapy on diabetic nephropathy. Methods 120 patients with diabetic nephropathy (DN) were randomly divided into observation group, control group A and control group B three groups, 40 cases each. The changes of blood pressure and 24h urine protein before and after treatment were observed. Results After treatment, blood pressure and urinary protein decreased significantly in all three groups (P <0.05). The degree of decrease in the observation group was greater than that in the A and B groups (P <0.05). Conclusion The combination of benazepril and valsartan is more effective and safe than DN alone.