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目的:考察注射用头孢西丁钠与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法:在(25±1)℃下,采用高效液相色谱法(HPLC)测定配伍液8 h内头孢西丁钠与氯诺昔康的含量变化,并观察和检测配伍液的外观、pH及不溶性微粒变化。结果:8 h内配伍液外观、pH、不溶性微粒及氯诺昔康的含量无明显变化,头孢西丁钠含量不断下降,8 h含量为95.5%。结论:室温条件下,注射用头孢西丁钠与注射用氯诺昔康在0.9%氯化钠注射液中8 h内保持稳定。
Objective: To investigate the compatibility of cefoxitin sodium for injection and lornoxicam for injection in 0.9% sodium chloride injection. Methods: The contents of cefoxitin sodium and lornoxicam were determined by high performance liquid chromatography (HPLC) at (25 ± 1) ℃ within 8 h, and the appearance, pH and Insoluble particulate changes. Results: The contents of pH, insoluble particles and lornoxicam did not change within 8 h. The content of cefoxitin sodium decreased continuously, and the content of cefoxitin sodium was 95.5% after 8 h. Conclusion: At room temperature, cefoxitin sodium for injection and lornoxicam for injection remain stable within 8 h in 0.9% sodium chloride injection.