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非甾体抗炎药(NSAIDs)应用于临床已有100多年的历史,具有抗炎、镇痛效果,广泛应用于风湿性疾病、类风湿性疾病、炎性疾病、疼痛、软组织和运动损伤、痛经及发热的治疗,近年经过研究逐步用于心血管疾病及肿瘤的预防。目前,NSAIDs是全球处方量最大的药物之一,但使用NSAIDs的患者中约1/3发生药物相关不良反应,10％患者需停药。NSAIDs的使用也增加了患者住院和死亡风险。
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used clinically for more than 100 years and have anti-inflammatory and analgesic effects. They are widely used in rheumatic diseases, rheumatoid diseases, inflammatory diseases, pain, soft tissue and sports injuries, Dysmenorrhea and fever treatment, in recent years after the study gradually used for cardiovascular disease and cancer prevention. Currently, NSAIDs is one of the most prescribed drugs in the world, but about one-third of NSAIDs have drug-related adverse reactions and 10% require discontinuation. The use of NSAIDs also increases the patient’s risk of hospitalization and death.