DNA结合抑制因子(DNA-binding inhibitory factor,Id)属于螺旋-环-螺旋(helix-loop-helix,HLH)转录因子家族,是细胞分化的负性调控因子,目前在哺乳类动物细胞中发现含有4种Id因子Id-1至Id-4,其在肿瘤中常有过度表达,并与肿瘤的侵袭转移有密切的相关性,近年来的研究表明,其在对肿瘤的治疗上有望成为肿瘤治疗的新靶点。 DNA-binding inhibitory factor (Id) belongs to the family of helix-loop-helix (HLH) transcription factors and is a negative regulator of cell differentiation. At present, it is found in mammalian cells that it contains The four Id factors Id-1 to Id-4, which are often overexpressed in tumors and are closely related to tumor invasion and metastasis, have been shown in recent years that they are expected to become tumor therapy in the treatment of tumors New target