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目的:奥曲肽与普萘洛尔在肝硬化上消化道出血患者中的血流动力学变化作用。方法:将2013年1月至2015年1月在我院接受治疗的90例肝硬化上消化道出血患者,随机分为观察组45例(应用奥曲肽与普萘洛尔联合治疗)和对照组45例(单纯给予奥曲肽进行治疗),对比两组患者的临床治疗效果。结果:两组患者治疗门静脉及脾静脉血流量均显著减少(P<0.05),其中观察组治疗后门静脉血流量为(559.2±147.6)ml,脾静脉血流量为(285.1±100.1)ml,均显著低于对照组,两组相比差异具有统计学意义(P<0.05)。结论:针对肝硬化上消化道出血患者采用奥曲肽与普萘洛尔联合治疗后,患者门静脉及脾静脉血流量明显减少,临床治疗效果显著,值得临床推广应用。
Objective: The effects of octreotide and propranolol on hemodynamic changes in cirrhotic patients with upper gastrointestinal hemorrhage. Methods: From January 2013 to January 2015 in our hospital for treatment of 90 cases of cirrhosis patients with upper gastrointestinal bleeding were randomly divided into observation group 45 cases (application of octreotide and propranolol combination therapy) and control group 45 Cases (treated with octreotide alone), compared the clinical efficacy of two groups of patients. Results: The blood flow of portal vein and splenic vein were significantly decreased in both groups (P <0.05). The portal vein blood flow in the observation group was (559.2 ± 147.6) ml and the splenic vein blood flow was (285.1 ± 100.1) ml in both groups Significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: The combination of octreotide and propranolol in cirrhotic patients with upper gastrointestinal bleeding significantly reduces the blood flow in the portal vein and splenic vein. The clinical curative effect is remarkable and worthy of clinical application.