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基因治疗面临的首要技术问题是基因药物的载体,目前用于基因治疗的载体主要分为两大类:病毒载体和非病毒载体。病毒载体虽然在基因转移方面具有一定的优点,但在体内具有较大的潜在危险,限制了它在临床基因治疗上的应用。非病毒载体中最具典型的是阳离子脂质体(cationicliposome
The primary technical problem facing gene therapy is the carrier of gene drugs. At present, the vectors used for gene therapy are mainly divided into two categories: viral vectors and non-viral vectors. Although the viral vector has certain advantages in gene transfer, it has a great potential risk in the body and limits its application in clinical gene therapy. The most typical non-viral vectors are cationic liposomes