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在过去的四十年里,结肠和直肠腺癌的发病率一直没有变化.引起该肿瘤的病因至今不明.尽管人类认识到病毒感染与其它肿瘤有关已有四分之三个世纪,但尚无人提出病毒可引起结肠癌.早已证实泌尿生殖器和消化道的鳞状细胞癌与感染人类乳头瘤病毒(HPV)有关,而且证实这种关系在诊断和监测这些疾病时有临床价值.在结肠癌能证明有似的关系,或许对此病将起相同的作用.作者新近证实HPV抗原与良性、恶性结肠肿瘤之间有关联.但这类研究仅证实病毒相关蛋白,而不是病毒基因.原位DNA杂交是一项对该病毒基因既快又具可重复性的试验,且该基因对此病毒感染具有特异性.作者用免疫组织化学法探测HPV抗原来筛选结肠组织,其中包括30例正常粘膜,30例良性肿瘤,43
In the past 40 years, there has been no change in the incidence of colon and rectal adenocarcinomas. The cause of this tumor has remained unknown. Although humans have recognized that viral infection has been associated with other tumors for three-quarters of a century, they have not yet been identified. It has been proposed that the virus can cause colon cancer. It has long been confirmed that squamous cell carcinoma of the genitourinary and digestive tracts is associated with human papillomavirus (HPV) infection, and it is confirmed that this relationship has clinical value in the diagnosis and monitoring of these diseases. Can prove a similar relationship, perhaps the disease will play the same role. The author recently confirmed that HPV antigen and benign, malignant colon tumors are related. However, such studies only confirmed the virus-related protein, not the virus gene. DNA hybridization is a test that is rapid and reproducible for the virus gene, and the gene is specific for this virus infection. The authors used immunohistochemical detection of HPV antigen to screen colon tissue, including 30 cases of normal mucosa. , 30 cases of benign tumors, 43