急性白血病50例随机分为米托葸醌(加MTZ)及胺吖啶(AMSA)为主方案治疗组。两组1疗程达缓解者均较多,缓解率及总育效率无显著性差异,初治病例均好于复治病例。主要毒性反应均表现骨髓抑制,但AMSA组的消化道毒性反应更频繁,程度更重,持续时间更长,而MTZ组剂量与疗效关系更大。 Fifty cases of acute leukemia were randomly divided into mitoxantrone plus (MTZ) and ameporidine (AMSA)-based regimen treatment groups. There were more remissions in both groups, and there was no significant difference in remission rate and total education efficiency. The initial cases were better than retreatment cases. The main toxicities all showed myelosuppression, but the toxicity of the gastrointestinal tract in the AMSA group was more frequent, the degree was heavier, and the duration was longer, whereas the dose and effect of the MTZ group were more related.