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目前治疗白血病主要依赖化学药物对抗细胞增殖的机理上,用较大剂量的多种细胞毒药物联合化疗,使骨髓抑制而取得完全缓解,几年来强烈的联合化疗使白血病缓解率及缓解期有显著提高,但近年来疗效较稳定,未再进一步提高。小剂量阿糖胞苷(Ara-C)在体外实验证实,某些经典的细胞毒剂,在小剂量时能改变白血病细胞增殖进程中的失调,并诱导它们向成熟分化。
The current treatment of leukemia mainly rely on the mechanism of chemical drugs against cell proliferation, with a larger dose of a variety of cytotoxic drugs combined with chemotherapy, bone marrow suppression and achieved complete remission, strong combination of chemotherapy over the past few years to leukemia remission rate and remission were significant Improve, but in recent years the effect is more stable, no further improvement. Low-dose cytarabine (Ara-C) experiments in vitro confirmed that some classical cytotoxic agents can alter the imbalance of leukemic cell proliferation processes and induce their differentiation toward maturation at low doses.