目的了解住院患者注射用质子泵抑制药的使用情况,促进这类药物的安全、有效、合理应用。方法基于循证原则,制定注射用质子泵抑制药应用评价标准,随机抽取郑州大学第一附属医院2012年363份住院患者病历,针对注射用质子泵抑制药使用过程中的适应证、给药时机、用药疗程、使用剂量及频率、溶媒选择等方面进行评价分析。结果大部分住院患者注射用质子泵抑制药使用合理。抽查的5个科室中,各科室注射用质子泵抑制药符合适应证应用的合格率分别是:重症监护室100.0%,消化内科43.2%,呼吸内科74.2%,骨科60.7%,肾内科90.0%。不合理应用情况主要表现在无明确适应证用药或用药级别过高、给药疗程偏长等。结论注射用质子泵抑制药临床应用广泛,应当建立用药评价标准,并依据评价标准,针对不同患者的不同情况调整给药方案,注意合理用药。 Objective To understand the use of proton pump injections in hospitalized patients and to promote the safe, effective and rational use of these drugs. Methods Based on the evidence-based principle, the evaluation criteria of proton pump inhibitor for injection were established. 363 hospitalized patients were randomly selected from the First Affiliated Hospital of Zhengzhou University in 2012 for indications of the use of proton pump for injection and the timing of administration , Medication course, the use of dose and frequency, solvent selection and other aspects of evaluation and analysis. Results Most hospitalized patients with proton pump inhibitors used in medicine is reasonable. Among the 5 departments sampled randomly, the qualified rate of application of proton pump inhibitor in each department is: 100% in intensive care unit, 43.2% in gastroenterology, 74.2% in respiratory medicine, 60.7% in orthopedics, and 90.0% in nephrology. Irrational use of the situation mainly manifested in the absence of a clear indication of medication or medication level is too high, long course of treatment. Conclusion The proton pump inhibitor for injection has a wide range of clinical applications. Evaluation criteria for drug use should be established. Based on the evaluation criteria, the dosage regimen should be adjusted according to the different conditions of different patients, and attention should be paid to rational use of drugs.