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脂滴是一个复杂且活动旺盛的多功能细胞器,基本功能主要参与脂类合成和贮存,脂滴相关蛋白参与了多种脂质关联生物学过程,包括细胞信号转导、脂代谢的调控、膜运输、炎症相关蛋白的合成与分泌等。近年来关于脂滴与免疫应答反应的研究表明,根据细胞所处的阶段或状态不同脂滴存在不同的亚群,发挥特异性细胞功能。病原微生物的感染与细胞内脂积累密切相关,在免疫因子合成、抗原递呈、自噬等免疫过程中脂滴参与并起到关键的作用。本文针对脂滴在免疫应答反应方面的最新研究进行综述。
Lipid droplets are a complex and highly active multifunctional organelles. Their basic functions are mainly involved in lipid synthesis and storage. Lipid-associated proteins are involved in a variety of lipid-related biological processes, including cell signaling, regulation of lipid metabolism, Transport, synthesis and secretion of inflammation-related proteins. In recent years, studies on the reaction of lipid droplets with immune response show that different lipid droplets exist different subpopulations depending on the stage or state of the cells and exert specific cell functions. The infection of pathogenic microorganisms is closely related to the accumulation of intracellular fat, and lipid droplets are involved in the immune processes such as synthesis of immune factors, antigen presentation and autophagy, and play a key role. This review summarizes the latest research on lipid droplets in immune response.