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目的探讨复方丹参滴丸治疗颅脑外伤伴发间脑癫痫的作用机制。方法 90例颅脑外伤伴发间脑癫痫的患者,随机分为对照组41例,予常规抗癫痫对症治疗;治疗组49例,在常规治疗基础上,另加服复方丹参滴丸1,0粒/次3,次/d,3个月后观察疗效并复查脑电图,同时监测治疗前后及癫痫发作时的血浆一氧化氮(NO)含量水平。结果临床疗效除癫痫症状无改善者外,将满意、显著改善、良好及效差均列为有效,治疗组总有效率达89.8%,对照组为73.2%(P<0.05);两组治疗前后脑电图表现为棘波、慢波和棘慢波综合者或弥漫性放电者疗效比较,差异无统计学意义(P>0.05);治疗组治疗后血浆NO水平高于治疗前,低于发作时,高于对照组水平(均P<0.05)。结论复方丹参滴丸治疗颅脑外伤伴发的间脑癫痫,疗效确切;但针对脑电图表现为棘波、慢波和棘慢波综合者或弥漫性放电者疗效无明显特异性。临床疗效可能与其改善脑部血液循环障碍、促进血脑屏障(blood brain barrier,BBB)生理性开放及调节血浆NO水平有关。
Objective To investigate the mechanism of Fufang Danshen Diwan in the treatment of cerebral epilepsy associated with craniocerebral injury. Methods Ninety patients with craniocerebral trauma accompanied by epilepsy were randomly divided into control group (n = 41) and conventional antiepileptic symptomatic treatment (n = 49). On the basis of conventional treatment, Granules / times 3, times / d, 3 months after the observation of efficacy and review of EEG, while monitoring before and after treatment and seizure plasma nitric oxide (NO) levels. Results The clinical efficacy except those with no improvement of epilepsy was satisfactory, significantly improved, both good and effective were listed as effective. The total effective rate was 89.8% in the treatment group and 73.2% in the control group (P <0.05) EEG showed spikes, slow wave and spike and slow wave comprehensive or diffuse discharge efficacy comparison, the difference was not statistically significant (P> 0.05); the treatment group after treatment of plasma NO levels higher than before treatment, lower than the attack When compared with the control group (all P <0.05). Conclusions Compound Danshen Dripping Pill is effective in treating epilepsy with epilepsy associated with craniocerebral trauma. However, there is no obvious specificity in treating electroencephalography (EEG) with spike wave, slow wave, spike and slow wave syndrome or diffuse discharge. The clinical efficacy may be related to improving the blood circulation disorder of the brain, promoting the physiological opening of the blood brain barrier (BBB) and regulating the plasma NO level.