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[目的]观察长期饮酒对腹腔镜结肠肿瘤切除患者术后阿片类药物镇痛效果的影响。[方法]选择择期行腹腔镜结肠肿瘤切除术患者60例,按照患者是否长期饮酒分为长期饮酒组与对照组。全麻术后予以静脉镇痛泵镇痛(舒芬太尼2.5μg/kg+托烷司琼4mg),术后记录所有患者镇痛泵的实际按压次数与有效按压次数,并采取视觉模拟评分法(VAS)评估患者不同时间段的疼痛程度。并记录所有患者恶心呕吐、呼吸抑制、低血压等不良事件的发生。[结果]长期饮酒组患者镇痛泵的实际按压次数和有效按压次数均显著高于对照组,术后各时间点VAS评分亦较对照组显著增高;两组患者恶心呕吐、低血压发生率无统计学差异,且均未出现呼吸抑制现象。[结论]在相同的条件下,长期饮酒组患者术后阿片类药物镇痛效果差,需要更大剂量的阿片类药物才能满意的镇痛效果。
[Objective] To observe the effect of long-term alcohol consumption on postoperative opioid analgesia in patients undergoing laparoscopic colon tumor resection. [Methods] Sixty patients undergoing laparoscopic resection of colon cancer undergoing elective resection were divided into long-term drinking group and control group according to whether the patients were drinking for a long time. After general anesthesia, intravenous analgesia was used to induce analgesia (sufentanil 2.5 μg / kg + tropisetron 4 mg). The actual number of compression and effective compression of analgesia pump in all patients were recorded after operation and visual analogue scale (VAS) to assess the patient’s pain at different time periods. All patients were recorded nausea and vomiting, respiratory depression, hypotension and other adverse events. [Results] The number of patients and the effective press times of analgesic pump in long-term drinking group were significantly higher than those in control group. VAS score at each time point was significantly higher than that in control group. The incidence of nausea, vomiting and hypotension Statistical differences, and no respiratory depression. [Conclusion] Under the same conditions, postoperative opioid analgesia in long-term drinking group patients is poor, and larger doses of opioids are needed to achieve satisfactory analgesic effect.