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目的评价女性乳腺癌部分行为危险因素的作用,为乳腺癌的病因学研究和预防提供依据。方法运用Meta分析方法对国内外2001-2010年间公开发表的有关乳腺癌行为危险因素病例对照研究的30篇文献资料进行定性综合分析。结果哺乳、饮酒、流产、主动吸烟、口服避孕药合并OR值分别为0.71(0.60～0.85)、0.78(0.49～1.24)、1.43(0.88～2.31)、1.05(0.98～1.13)及1.11(0.93～1.33),敏感分析前后差别不大,被动吸烟敏感分析前后合并OR值分别为1.45(1.11～1.90)和1.06(0.85～1.31),得出结论不一致。结论被动吸烟是女性乳腺癌发生的危险因素,哺乳是保护因素,不能得出饮酒、主动吸烟及口服避孕药与女性乳腺癌发生危险有关联的结论。
Objective To evaluate the role of some behavioral risk factors in breast cancer in women and provide basis for the study and prevention of breast cancer. Methods Meta-analysis was used to qualitatively and comprehensively analyze 30 literatures published in the case-control study of risk factors of breast cancer between 2001 and 2010 both at home and abroad. Results The combined OR of lactation, drinking, abortion, active smoking and oral contraceptives were 0.71 (0.60-0.85), 0.78 (0.49-1.24), 1.43 (0.88-2.31), 1.05 (0.98-1.13) and 1.11 1.33). There was no significant difference between before and after the sensitive analysis. The combined OR before and after the sensitive analysis of passive smoking were 1.45 (1.11-1.90) and 1.06 (0.85-1.31), respectively. The conclusion was inconsistent. Conclusions Passive smoking is a risk factor for breast cancer in women. Breastfeeding is a protective factor and can not be concluded that alcohol consumption, active smoking and oral contraceptives are associated with the risk of breast cancer in women.