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目的探讨抗环瓜氨酸多肽(CCP)抗体在类风湿因子(RF)阳性患者血清中的表达及其在类风湿关节炎(RA)不同时期的表达和临床意义。方法对90例RF阳性患者分为两组,包括74例RA患者组及15例非RA患者组,进行抗CCP检测;同时把74例RA患者分为急性发作期及缓解期,对其抗CCP检测结果进行分析比较。结果经卡方检验,两组患者抗CCP阳性率存在显著差异,RA组明显高于非RA组(χ2=11.47,P<0.001);经t检验,两组患者抗CCP所测数据存在显著差异,RA组明显高于非RA组(t=8.86,P<0.005)。同时,把RA组患者分为急性发作期组和缓解期组,两组患者抗CCP检测数据存在显著差异,急性发作期组明显高于缓解期组(t=11.16,P<0.001)。结论抗CCP检测可提高RA的诊断特异性,并对其治疗效果及预后观察具有重要的意义。
Objective To investigate the expression of anti-cyclic citrullinated peptide (CCP) antibody in sera of rheumatoid factor (RF) -positive patients and its expression in different stages of rheumatoid arthritis (RA) and its clinical significance. Methods 90 patients with RF positive were divided into two groups, including 74 patients with RA and 15 patients with non-RA, anti-CCP test; at the same time, 74 cases of RA patients were divided into acute attack and remission, its anti-CCP Test results for analysis and comparison. Results There was a significant difference in the anti-CCP positive rate between the two groups. The RA group was significantly higher than the non-RA group (χ2 = 11.47, P <0.001) .Through t-test, there was significant difference , The RA group was significantly higher than the non-RA group (t = 8.86, P <0.005). At the same time, patients in RA group were divided into acute exacerbation group and remission group. There was significant difference between the two groups in the anti-CCP test data. The acute exacerbation group was significantly higher than the remission group (t = 11.16, P <0.001). Conclusion The anti-CCP test can improve the diagnostic specificity of RA, and is of great significance for its therapeutic effect and prognosis.